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期 刊 ：中国中药杂志 2005年 30卷 20期 页码：1587.

关键词：喷雾制粒；颗粒剂；制备工艺；正交实验；

Keywords:spraying granulation, granules, preparation, orthogonal experiments,

摘 要 ：目的:为提高喷雾制粒颗粒的成品率及提高经济效益,需要筛选制备工艺。方法:采用新型喷雾制粒机制粒,以浸膏的提取工艺、黏合剂的用量、进出口的风温及辅料的配比为考察因素,每个因素2个水平,以颗粒的成品率为考察指标,采用正交试验设计法优选出最佳喷雾制粒工艺。结果:4因素中以黏合剂的用量影响最为明显,其次为进出口风的温度。浸膏的提取工艺及辅料的配比影响不大。结论:保肾颗粒剂最佳的喷雾制粒工艺条件为蔗糖与环糊精的配比为2∶1;进风口的温度为90~100℃;出风口的温度为50~60℃;黏合剂的用量为0.5%。提取液以不经过醇沉为佳。

Abstract:Objective: To raise the end-product and economical efficiency of spraying granulation,we demand screening preparation technique.Method:Adopting newly spraying granulation technique,taking extracting technique,adhesive material, temperature of exit and entry,and the matching of accessories as inspecting factors,two levels of each factors,end-product as inspecting marker,we selected the best Baoshen granules preparation technique by orthogonal design. Result: Among the 4 actors,adhesive material is most notable,next is temperature of exit and entry,the other two is of little importance.Conclusion: The optimum spraying granulation technique of Baoshen granules is A₂B₁C₂D₁.

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