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期 刊 ：中国中药杂志 1998年 23卷 09期 页码：533.

关键词：蟾皮；炮制；脂蟾毒配基；高效液相色谱；

Keywords:Pellis Sicci Bufonis, processing, recibufogenin, HPLC,

摘 要 ：目的：探讨蟾皮经水烫炮制后脂蟾毒配基含量变化。方法：采用高效液相法测定。结果：３批蟾皮中脂蟾毒配基含量依次为（ｍｇ／ｇ）：０.６２５３，０.６１０２，０.６４３３；对应３批水烫炮制品含量为（ｍｇ／ｇ）：０.７８６４，０.７７１６，０.７９８６。平均回收率９８.３４％，ＲＳＤ＝１.２８％。结论：蟾皮水烫炮制品较生品中脂蟾毒配基含量略高。

Abstract:Objective:To investigate the effect of scald processing on the content of recibufogenin in Pellis Sicci Bufonis.Method:Samples were analyzed by high performance liquid chromatography.Result:The content of recibufogenin in the scald processed product was 25.7% higher than that in the unprocessed one.The average recovery was 98.34% and RSD 1.28%.Conclusion:The results indicate that the content of recibufogenin in scald processed Pellis Sicci Bufonis is higher than that in the unprocessed drug.

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