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期 刊 ：中国中药杂志 1999年 24卷 02期 页码：91.

关键词：蛇胆；稳定性；结合胆汁酸；牛磺胆酸钠；

Keywords:snake gall, stability, conjugated bile acids, sodium taurocholate,

摘 要 ：目的：考察蛇胆主要有效成分牛磺胆酸钠在２５％乙醇液中和人工胃液中及其在热压灭菌过程中的稳定性。方法：该溶液的稳定性预测采用恒温加速试验法，其含量测定借助薄层 比色法。结果：２５℃时牛磺胆酸钠在２５％乙醇液中的半衰期（ｔ_1/2）为６０．５７ｄ；３７℃时在人工胃液中的半衰期为１１．３７ｄ；其水溶液在１１５℃，３０ｍｉｎ灭菌条件下，牛磺胆酸钠损失率为３％。结论：牛磺胆酸钠在２５％乙醇水溶液中不稳定。建议增大乙醇浓度，并将其贮藏在０℃以下。

Abstract:Objective:To investigate the stability of the main active constituent of snake gall sodium taurocholate,TCANa in 25% alcoholic solution and artificial gastric juice,and in the course of hot pressurized sterilization.Method:The stability of the solution was predicted by an accelerated isothermal test,and the content of TCANa was determined by TLC colorimetery.Result:The half time(tl/2)of TCANa in 25% alcoholic solution is 60.57d at 25℃,and in artificial gastric juice 11.37d at 37℃,the loss rate under the condition(115℃,30min)of sterilization about 3%.Conclusion:TCANa in 25% alcoholic solution is unstable.Therefore it is suggesed that in order to raise the stability of TCANa the alcoholic concentration be increased and the solution be stored at temperatures below 0℃.

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