Abstract:The extraction and purificatory crafts for Radix Sophorae Flavescentis were observed through the orthogonal ex-periment design using matrine as the fixed indicatrix for TLC-scanning.Quantitative analyses of matrine were made on the momentum parameters of the different craft conditions.The results of the three different extraction methods showthat the best way is to use 2% gelatin to remove tannin with the least loss of matrine,and that the ethanol extractfrom water precitation is better than the water extract from ethanol precipitation.