免费文献传递   相关文献

Research progress of anti-drug resistance in traditional Chinese medicine

中药抗细菌耐药性的研究进展



全 文 :2016
y

z ©
41
ª©

}
Vol41,No.5 March,2016
$,¾¿ÀÁ,Ž˜™¼½
uv
1,
wxy
1,
]z:
2,
]
3,
{|
1,
!E
1,
}&~
4
(1
5åçXZ?¨ Z¨Y

5å ¥
330006;2
5åæçèéüXY

5å ¥
330000;
3
5åçXZ?¨ cdê©ü«ç=

5å ¥
330006;
4
5åçXZ?¨ gÅX¨Y

5å ¥
330006)

op
] 
¿ÀÁ,Â[6«wóZ¶ŽÎq«¬

(¡Sé18_,¾©ìŽäʑ

>…¿À

ŽêÂ]ü

¿ÀÁ,
±ٕŽŒßýmD¬

-B]îKôŽ±

o_,¾©ìY±þïŽÌ°

ÙPÛÙ¥Ž9+ÿ¿:>E>

5
w°

SÄÉÊ:

¾Á,fôñ!Ž$T,

Hç8$ïÎâ©Á,«¬ŽÚ_`rڅN

ÝÔy:LM

Ñ-

‡=°ä\.Ë$,$BWŽÁ,Kô|

œÌ¾Á,Âfô

0¯,”,˜™Žåq

µ^8¿ÀÁ,ŽÉÊf
ô

$,¾¿ÀÁ,Ž¡qËܱ

¾ÁŽ$,‡„,ñ•”¼n¿‡§‘u’

Hç¯â©¿ÀÁ,«¬‘˜
mÚØ$,²>¾©ìÑ6[׎ÈÀ£»Ë˜™…N


qr‰
] 
¿À

Á,Â

$,

²>¾©ì

tu)(
] 20151003

vwxT
] 
@`‹Œü¨g*xy
(81173565);
5卋Œü¨g*xy
(20142BAB205083);
5南fëü¨«¬qrxy
(GJJ13609);
5åýé8éìçXZüq8ßxy
(2015A049)

yzA{
] 
!E

—°

žŸéÏj

qr‡ˆˆçZHíî

H«¬áH•ïÌqð
,Tel:(0791)87118658,Email:yangming16@
126com;
}&~

ñj

qr‡ˆˆçZòóħᢣ
,Tel:(0791)87118907,Email:43738545@qqcom

A{„…
] 
uv

žŸ

͗°

qr‡ˆˆçZHíînH«¬
,Tel:(0791)7118645,Email:hanfei8454871@163com
Researchprogressofantidrugresistancein
traditionalChinesemedicine
HANFei1,XINGRenhui1,CHENLinqi2,CHENLai3,XIONGWei1,YANGMing1,ZHAOZhidong4
(1ColegeofPharmacy,JiangxiUniversityofTraditionalChineseMedicine,Nanchang330006,China;
2JiangxiProvinceDermatosisSpecialHospital,Nanchang330000,China;
3LaboratoryAnimalScienceandTechnologyCenter,JiangxiUniversityofTraditionalChineseMedicine,Nanchang330006,China;
4BasiMedicalColege,JiangxiUniversityofTraditionalChineseMedicine,Nanchang330006,China)
[Abstract] BacterialdrugresistancehasbeenalwaysthefocusoftheworldWiththeabuseofantibioticsandtheemergingof"Su
perbug"intheworld,theharmofdrugresistancetohumanbeingsismoreandmoreserious,withanuncontrolabletrendToday,with
therelativelackofantibiotics,peoplepaymoreatentiontoChineseherbalmedicineswithawiderangeofsources,highsecurity,less
toxicsideefectsandmysteriousantidrugresistancemechanism,hopingtofindnewwaysornewideastosolvetheproblemofdrugre
sistanceInrecentyears,thescreening,extractingandisolatingofefectivedrugresistanceinhibitorsfromnaturalplantsandtradition
alChineseMedicine,aswelastheinvestigationinmechanismofantidrugresistance,havebecomeahotresearchinthefieldofmedi
cineInthispaper,wewouldanalyzeandsummarizetheactionmechanismofbacterialdrugresistance,characteristicsandadvantages
ofantidrugresistanceoftraditionalChinesemedicine,aswelastheherbalingredientswithantidrugresistanceefect,hopingtopro
videcertaintheoreticalbasisandresearchideasforsolvingtheproblemofbacterialdrugresistanceanddevelopingnewgreenChinese
antibiotics
[Keywords] bacteria;drugresistance;traditionalChinesemedicine;greenantibiotics
doi:10.4268/cjcmm20160509
·318·
2016
y

z ©
41
ª©

}
Vol41,No.5 March,2016
  
!È¿ÀÁ,Ž£¤

,¤«#(¾©ì$©&O¯
æoŽ
[1]。
¿Àãۓ”çæí&

Á,Â[zÖ©


î@Ò£®W´^[2]。
(
_,¾©ìŽE>^Ê

¿ÀÁ,Â0¯wó_Ž«¬
¿

äʾ©ì‘tÖ©«,Á,Â

ù&Á,Ž]Rw
&

Ô,y:…Š¿Á,Âí&Ž

>…¿À
”,“
¥,
Á,À

„

B›³´

üyÍ ‚¾©ìŽäÊ

¿À
Á,Ž«¬#Š12KôŽ±

ðñٕ#+µÎ

¾©ìmŠ&ý

ŽOP

ÎOîçémwóŒf

­
â©¿ÀÁ«¬

]Ú²ôî‘åtYZŽ¶‚‘ô
±

ù&¾©ìŽŒ‘ÇÈ

ù-²ìí˜mÚ؎

$,²>¾©ì
”,
!œ¬Ì¿ÀÁ,Žfô‘¡q

4^¯Ôy:

$,¾¿ÀÁŽ˜™‘Š‹¼nËÁ

Hç¯â©¿ÀÁ,«¬Ñ6[׎¹Ì

1 
¿ÀÁ,ÂÖ©Žfô
11 
6WÁ,Â
6WÁ,Â;­Í6W£®Žàô

‡¯>öÁ,Â
‘ŸïÁ,Â

>öÁ,«,¤>ö£®ê“Ö©
ŽÁ,Â

@缾[/¾©ìÖ©Á,Â

ùŸïÁ,Â
«¿ÀÖ©6WÁ,Ž;­fô

¿ÀŽŸï[DQd
Ÿï

¾ÂŸï
、Col
Ÿï

܂Ÿï‘_âŸï„

Ì$
¾ÂŸïß]

Ÿï



˜™mŠÑÛ>ûüóÀ

w


f7>À

x²Š#jÀ„ö8º,B

Ÿï

n.
¿À%‘tÖ©Á,Â
,^
¥=/•Ž¾©ì-Wr-°

ÙB{›

>…¿À
”———
Áë^K¹ÑÛ>ûüóÀ
(MRAS),
íwŒß¿Ù•ŽÜݑ©

²ré–H¾Ž¬
¢‘Z¶

12 
©.Á,Â
¿À©.Á,fôŽÖ©;­‡¯

•
:①@ÒÖ©&
°$r_$

8ùA˜x/¾À,.

9ý;­mŠŽB
β8À($•、#£gĕ&°$、Ւì•_$、)’ì
À£¼À$„
;②¿À¿jí@„ÂŽs“,,¤ý}Ê,,
¿ÀÖí¦·’§m©s“
,^
á¿ÀÖí@„Âm©s
“

¼ùÃ*¾©ì¼‚¿j8
;③ÉÊpXŽs“,¿Ào
¾À,.ŽÉÊLÖ©£®ê“
,^
á±²Ö©pX¦·Ž
’§rÈ_Ÿm©s“

¼ùÖ©Á,Â
;④Pz_`Ž


¿Àî2@Òs“ãێPz_`úá±,.ŽÁÍ
Â
;⑤;ŠÖÌõÁ,fô,;ŠÖÌõ«¿jí¼Ž[•
¦·Ÿ

ç¾#¼‚¿À8Ž¾À,.¡ÿŽ;Šõ¿


8ùúáÂÁ,Â

ª¿À¥¬Á,ÂBZŽ;ŠÖ
Ìõ

ñ¬;
[3]:ATP
’ñ+¼<ö•
(ABC)、

t_>¬;
(MFS)、
¥¬,.ª,.Ö̬;
(MATE)、
,.
ªPz.¼<ö¬;
(DMT)、
ÁÍ

©l

‡¹¬;
(RND)。
2 
$,Ž¾Á,Â
21 
$,¾¿ÀÁŽܱ‘¡q
(¿ÀÁ,«¬Žwó_

$,ɯÚØ¿ÀÁ,
Kô|÷:÷ÍÎw¬ŽZ¶

]øtj

$,oœ$²
Ê0B,éyŽ£¤

,¤Ì:>E>

5w°

SÂ:

OmBª_,]Ž¾Àfô

0¯¿ÀÁ,˜™
”,Žåq

Y§ª_,:z

$,¥¯ð•{‡å

x
‡&ÊmB[×YSZŸ

@ï󊯾ö WÉÊ

!
]“#ÉʤIñ#[Žpq

Ý]‘tÖ©Á,Â

9
ý

,¤_,¾©ì>ä

Ú؎$,²>¾©ì4€Õ
$&Å

ÛmnæÏw

mBHAŽ²Êýñ

22 
$,¾¿ÀÁ,Žfô˜™
221 
$,Kôβ8À($Ž°Â o©.ö8β8À(
$Žæoç¾*â β8À(•¾©ìr_þÌ°Â。˜™
mŠÛN

w,
、¨
Ǩ

ðã{ŽÑ-+±β8À($ím
B]ŽKôÉÊ
[4]。
Œ.MåMŽÑ-.
[5]、
°HVÛ
ì
[6]、
7-y»Ž‹©.
SB202742[7]
„ÑmBKô β8À
($ŽWy

LÛl

Û7âSl

A‹FSÝ

wÛk±>
EçŽβ8À($BCàŽ_þÉÊ,O­-ç.Á¿Ì
ÉÊfô
[89]。
¸¹ì
、¸
¹9Ⅱ、¬½ÃÄ、wÛbc、ÛÜ
Û9„

/$,‡Ñî@ÒKô>Eç β8À($Ž°
Âùêξ¿ÀÁ,ŽÉÊ
[10]。
,úîx

$,Ë$,
Ñ-.zTmBKôβ8À($Ž°Â,8ùêÎKô¿À
Á,ŽÉÊ

222 
$,s“¿jíŽ@„Â
 
Ôy:

B^•kB$
,ŽBW‡îs“¿À¿jíŽ@„Â

ü

Û܎;­
‡ÛÜÄç¾Kô‘A˜¿ÀŽ©.íŸ^

‘ò/Ø0
ñÊOç¾w&±©.í8x²Š#jÀŽ¾À°Â

Ñ°
ÌÁ,Â
[11];
ÑÒc$²/»±Áú’ìŽÑÛ>ûüó
ÀŽ¿jímB[׎%&

î2Ñ°ÑÛ>ûüóÀŽJ
àÂ

¼ùÑ°¾À,.Ž¾ÀÉÊ
[12];
Ë$Ž1XTº
‘X2ºÑîÉʤ¿ÀŽ¿jí

s“Ì@„Â

A˜Ì
©.’§

Ñ°¿ÀŽJàÉÊ

-]tÖ©Á,Â
[13]。
y
Ö

[.$,umv­î@ÒA˜¿ÀŽ¿jíù–ξÀ
ÉÊ


8ùs“¿À¿j
íŽ@„Â

_þ¿j8Žº„Ì

$3̕ïPz

8ù^
¿j¯Ð
[14]。
$,ËÌBW‡s“¿À¿jíŽ@„Â
‘’§

fôCz

Wyà{

www&̾Á,ŽÉÊ

¹áö‚˜™

223 
KôÖÌõùÖ©Ž¾Á,Â
 
,.ÖÌõE>æ
o¤Å©>f‘ßÂÀ

XÀ$

«¿ÀÖ©¥¬Á,Â
Ž¬­fô&[
。Beck
„@o
1988
y¯mŠ¿45©.‰
î2‘¾i,.67Ö̦·
Pgp
8ùKôg¦·ŽÖš
™ç

_þi¿jŽÁ,Â

:ÆÑɯ[/©.‰

«©
[ñðmŠmBKô¿ÀÖÌõÉʎ.Ÿ
,Neyfakh
„
[15]
QökB¿:ÆÑmBKô¿ÀÖÌõŽŽÉÊ

O
Ster
mitz
„
[16]
@Ò#
5
ë^£wO<ì
(5MHC)
ª:Q‰

9
8‰
、¯
9fÆèñ^ÊOÑmŠ
5MHC
î2KôÑÛ
>ûüóÀ
NorA
¦·$±:Q‰ŽÖÌÉÊ

_þÑÛ>
·418·
\ 


$,¾¿ÀÁ,Ž˜™¼½
ûüóÀ±:Q‰ŽÁ,Â

cVWŽBW‡d»VW
ëìo[×G±Oî2KôÁ,À;ŠÖÌfô

wùÁ,
ÑÛ>ûüóÀö8¾©ìŽ:ì 

mu»¼Á,ŽÉ
Ê
[17]。
1‡Û9•_ñ.ÑmBKôÖÌõŽÉÊ

ü.
Daleaversicolor
ŽPzÖ.
4′,6′dihydroxy3′,5′dimethyl
2′methoxychalcon[18];
°äÖ.
epicatechin
‘
epigalocatechin
galate[19]
º«¿ÀÖÌõŽKô|

224 
FúÁ,Ÿï
 
˜™óCI.$,mBFúÁ,Ÿ
ï

»¼¿ÀÁ,ŽÉÊ

ü

wåZÍ

5ÊâS•,.
‚)

ÑÒc

ÛÜ

Û7

ÛN

é²+

(;

Ë$

hi
T

w,v

ƒ6v„

2ËYZŽð•ô|

ü[

ބ

ímBHAŽFúŸïÁ,ŽÉÊ
[20]。
DÕ¶
Ë+ªÁÑÛ>ûüóÀÉÊH

mŠÁ,ŸïFú’yª
â<=£²»>
(SDS)
±Ä{mBCàŽKÿ

ÏFúúÈ
ŽÁ,gCàÙw
[21]。
?5H„
[22]
#ÛÜĪÁùw’ì
‘M´fƎ¥¬Á,À*@]Š%ÀÉÊ

Á,ÀŽÇþ
KôG±
(MIC)
L_ËJà*Ñ

óCÛÜÄç¾Fú*@
]Š%ÀŽÁ,Ÿï

Að*@]Š%À±ùw’ì‘M´
fƎJàÂ

®®„
[23]
ʏ(;ŽÑ-+±x²Š#j
À%ÀŽ

Ÿï¼nFú

mŠ¿Ñ-+oö8ŽFúÉÊ
&¤öÖ

O1Ñ
[24]
ÊÛÜÄÑ-+‘¶&
[25]
Ê·òG
Ñ-+±x²Š#j%ÀŽ

Ÿï¼nFú

Ѻá•
Ž’y

FúÁ,Ÿï

«Ñ°¾Á,ÂÇ;­Ž_`&
[

$,0oFúÁ,Ÿï•”mõ°äŽÜ±

I.ÉÊ
îaP_,¾©ì

îëA⩎¿ÀÁ,«¬

3 
¾¿ÀÁÂ$,‡Ž¡qˇ§
Ôy:

0B[.$,‡ðmŠmB[׎¾¿ÀÁ
,ŽÉÊ


1,
Ì;­î‡¯2L,•

ó
1 
$,Ë$,‡¾¿ÀÁ,‡•
Table1 ClassificationofresistancetobacterialdrugresistanceofthetraditionalChinesemedicineandtheingredientoftraditional
Chinesemedicine
‡/• mö‡
©.‰  
:ÆÑ
[34]、
ýºFÔ
[14]、
:Q‰
[16]、
98‰
[16]、
cVWëì
[17]、5
ë^£wO<ì
[16]、
„¹‰
[35]、
„1[35]、
FJ“ì
[36]
Û9  
ÛÜÛ9
[10]、
к<§Û9
G[37]、¸
¹9Ⅱ[10]、:Qº\.$ŽÛ9Àpì•_ñ.5′methoxyhydnocarpinD[16]、BC
1Çì
A[38]
¥•‘umv
ÛFM$Býf¥8ˆ
(SLS)[39]、
ÂX=<¥•_ñ.xqT»
[40]、
w,v
[20]、
[14]、
ƒ6v
[20]
Dö‘ÃÄ
¬½ÃÄ
[10]、
Ù¹uÃÄ
[41]、
ÛÜÄ
[11]、
°HVÛì
[6]、¸
¹ì
[10]
º
X2º
[13]、
1XTº
[13]、¨
WE
[13]、
±

gFcì
[13]
bc
wÛbc
[10]、
·c¸c
[42]
ð•ô|
LÛl

Û7âSl

A‹FSÝ

wÛk
[89]、
[[43]、
åã-
[44]、
wægÆ
[45]、
ð•Ûô|
[21]
#‹$,  
ÑÒc
[46]、
é²+
[20]、
(;
[20]、
Ë$
[47]、
hiT
[20]、
G|8
[48]、
Aý<
[49]、
Û7
[50]、
FâT
[51]、
H
[52]、¨
Ç
¨
[4]、
öã{
[4]、
èéê
[53]、
MýT

IT

}·T

zJc

âw™K

[‰Ûc

L8{

ä}

ìcF„

Õc

gmT

Ñ^T
[54]、
ìT
[55]、
A‹<
[56]、
M]WT
[57]、
·òG
[58]、
·6N
[59]、
†í
[60]、
‹[61]、

[62]、
‘P
[63]、

[64]、
…
†‡
[65]
ÌØ
³Ä©
[66]、
QR
[67]、
:Qº\.ŽST•_ñ.èU6²ëˆ»
A[16]
  
4ÛámB¾ÀÉʎ_ñ.

n•_ñ.;­¯©
.‰•

Û9•

¥E•

umv•‘bc•„

©.‰$:
Q‰±Å©>fÂ

ß¿ÀºmBHAŽKôÉÊ

VW
‰±šØóÀ

ÑÛ>ûüóÀ

w%À

ÑY>h•%
ÀBëAŽL&ÉÊ-bxBÁ,ŽkB
[26];
Û9•$
ÛÜì‘ÛÜĪïʎò/•¾©ìèñ²ÊçBWw
þ¿ÀÁ,Žm©
[27];
wÛ$Ž™=`£bc•_ñ.
mBë&Ž¾À°Â

ËÌ«±ÑÛ>ûüóÀmB%&Ž
KôÉÊ
[2829];
¥E•‘umv•Ž‡ë¯ð-

9ýw
¥=ŽumvïrÉXq^Ê

,ÊY±ës

ÚÌ$Ž#
ö‡0B]sðmŠmB&ŽKÀÉÊ

ü@)umv$
Ž@)Ð

@)<9‘ βVXEímB%&Ž¾À°Â,-
oœ²ÊÒÓ$bxÌÖ©¿ÀÁ,Â

Ì/®îç«,
¤µ•‡îA˜¿ÀŽ¿j©.ð풧

vQ¿À&
°

ú•_ñ.Ž¾Àfô]¤_,¾©ì

-¥¯ð
•{‡å

îÉʤ¥ñpq

ݾÁ,Âë&

wåZ͕$,

µ•_ñ.;­«2$,ð•¯;

,‹¥„K

wåZÍæ&

;­Ê¤Íå€

O±?W
BHAŽ‘ÉÊ

­mB¾•‘ŒlföóôæŽÉÊ

¼ùw&föŽX¾æêξ¿ÀÁ,ŽÉÊ

üÛ7

ÛN

„¹

LÛl

A‹FS݄

ã
20
¡b¥ËÌ

±w
åZ͕$,FúÁ,ŸïŽYZkBêÂ]ü

÷äFú
}kB][

ÚÌFúÉÊ­«Y×æoŽ
[30]。
¨å
[31]
„
2$,Û7‘Û܎Ñ-.ɯŸïFú|

ÊZ‡

Ÿï
Ž¥¬Á,Âw[À¯˜™±C

7ÂÉÊ
48h,
Ÿï
Fú}êÎ
2257%,
8ù%AŽ€C¿wåZÍå•$,
«[/HAŽŸïÁ,ÂFú|

Ìؕ׎,.

n•,.;­«[.¾À°ÂŽ@
·518·
2016
y

z ©
41
ª©

}
Vol41,No.5 March,2016
A,.

ü³Ä©

èU6²ëˆ»

„

î2@Ò[.¼<
_`s“¿ÀŽ©È‹¾

Ñ°¾À,.Ž¾À°Â

¼ù
êξ¿ÀÁ,ŽÉÊ
[32]。
üâwwÓl

Ó$ðl
î2_þ\’ì‘ú’ìŽÇþKÀG±

Ñ°¿À±¾©
ìŽJàÂ
[33]。
÷än•,.4ÛàB¾À°Â

Úî2
s“¿À±¾À,.ŽJàÂ

Ñ°,.Ž‘W

4 
’§Ë½H
×%tƒR3

Fw.g

]BijŽ$,Î>

$,
mB]tÖ©Á,Â

SÄÉÊ:

øƒþO„Üq

®ú$
,¾Á,Ž˜™mBHAŽýñ

Ú9ý

$,¾¿ÀÁ
,Ž^•kB;­«2Fúr»¼¿ÀÁ,¯;

˜™È
ú¤[ñ-…ÃÄ

õ¥«¬­BÞ¼[玘™‘œ

$,¾¿ÀÁÂ;­æo2L«¬
:①YZ˜™w¥=oö
Ö¼n

±ö8Ž˜™Y±^d

,.oö8Ï
ADME
ÒÓ

m©¿íÌð-Ž©_“_

#ƎöÖTU«]ç¾w”
÷ø,.œŽ‘W

®úö8Ž¾ÀÁ,˜™BÞ¼[
çÌù
;②$,¾ÀÁ,Žfôk]«%Cz,TU¥_
Ž‡§ë¥

.Ÿ£»]¾Cz

‡<*ю£»˜™Y
±ës

ÉÊpqÈ`š¦

Õ­¼nÙùŸ^ö‚Ž˜™

nÑ«$,¾¿ÀÁ,˜mŽãÏ&N

¬$&¬
;③¼
n¾Á,˜™Žw¥¯#‹$,r«#[Ž‡

ð•ô
|Ž˜™k-]H

!]ç%AêÂ$,{•Ž¾ö™W‘
^€ÉÊ
;④˜™ŽÀ/Y±§ëÚ$,w¥«Z¤w%
À

ÑûÀ

x²Š#jÀ„

±¤ÌØQ?ÀŽ˜™ës

˜™é1BÞUw

o¿ÀÁ,Ž˜™$$,0¯Ç
BnŸŽ¾Á,Â.Ÿ

4€Õ$&Å

ÛmýñÏw

ù&
‡§‘ô|˜™*Ñ]RŽÑ°
,“
$,²>¾©ì

ãä+
O‚[ñaڎOP


|}?~

[1] WalshCMolecularmechanismsthatconferantibacterialdrugre
sistance[J]Nature,2000,406(6797):775
[2] 
®¸

!/^

$,»¼¿ÀÁ,Ž˜™¼½
[J]
œ‘
TUA-.
,2007,6(1):153
[3] SekiyaH,MimaT,MoritaY,etalFunctionalcloningandchar
acterizationofamultidrugefuxpump,mexHIopmD,froma
Pseudomonasaeruginosamutant[J]AntimicrobAgentsCh,
2003,47(9):2990
[4] 
Û@b

*c&



Kôβ8À($Ž$T,ŽeM˜™
[J]
fòwk
,2000,15(2):46
[5] GangouéPiébojiJ,BaurinS,FrèreJM,etalScreeningofsome
medicinalplantfromCameroonfrombetalactamaseinhibitoryac
tivity[J]PhytoterRes,2007,21(3):284
[6] EumkebG,SakdaratS,SiriwongSReversingβlactamantibiot
icresistanceofStaphylococcusaureuswithgalanginfromAlpinia
ofcinarumHanceandsynergismwithceftazidime[J]Phytomedi
cine,2010,18(1):40
[7] CoatesNJ,GilpinML,GwynnMN,etalSB202742,anovel
betalactamaseinhibitorisolatedfromSpondiasmombin[J]JNat
Prod,1994,57(5):654
[8] 
~xø

Ó-

L/$,•|±w[À>Eçβ8À(
$ŽKôÉÊ
[J]
$%A}-.
,2010,30(13):1097
[9] 
PC

*gh

±i

„

jÛ7

wÛk±Áw[À

Ÿï‘β8À($Ž%&[J]23$A,wk,2012,
35(2):105
[10] 
kñi

±„f

ŒÊl

$/$,#ö±Ö>Eçβ8À(
$w[À‘Áë^K¹ÑÛ>ûüóÀŽöÖKÀ°Â
˜™
[J]
$IœA…-.
,2011,5(2):540
[11] 
Õ/Ý
,¨
[&



„

ÛÜ*n+±x²Š#jÀ©.
ðíwúÉʎö֘™
[J]
$I’‘Çà-.
,2006,
29(5):347
[12] 


¿ÀÁ,ÂlñLŽ$,¾ÀÉʜ§
[J]
K1$
A,
,2013,26(6):122
[13] BouhdidS,AbriniJ,ZhiriA,etalInvestigationoffunctional
andmorphologicalchangesinPseudomonasaeruginosaandStaph
ylococcusaureuscelsinducedbyOriganumcompactumessential
oil[J]JApplMicrobiol,2009,106(5):1558
[14] 
“æ

#éi

[J]
$%XÀ-.
,2007,2(4):207
[15] NeyfakhAA,BidcilusVE,ChenLBEfluxmediatedmulti
drugresisitanceinBacilussubtilis:similaritiesanddissimilarities
withthemammaliansystem[J]ProcNatlAcadSciUSA,1991,
88(11):4781
[16] StermitzFR,PeterL,TawaraJN,etalSynergyinamedicinal
plant:antimicrobialactionofberberinepotentiatedby5′methox
hydnocarpin,amutidrugpumpinhibitor[J]ProcNatlAcadSci
USA,2000,97(4):1433
[17] BelofskyG,PercivilD,LewisK,etalPhenoliemetabolitesof
Daleaversicolorthatenhanceantibioticactivityagainstmodel
pathogenicbacteria[J]JNatProd,2004,67(3):481
[18] GibbonsS,MoserE,KaatzGWCatechingalatesinhibitmulti
drugresistance(MDR)inStaphylococcusaureus[J]Planta
Med,2004,44(2):428
[19] 
âù¹

Upq

+¼C

„

$,¾ÀÉÊË»¼Á,Âf
ô˜™
[J]
$rAA,-.
,2010,29(5):30
[20] 
*k¹

1©Õ

Z%s

w[ÀÁ,ŸïFú|˜™
¼½
[J]
Š.A¼½
,2009,30(1):89
[21] 
µx

±Õt

*u

ð•DÕ±ÑÛ>ûüóÀÁ,Ÿ
ïŽöÖFúËU
[J]
$%rA&
,2010,40(3):307
[22] 
?5H
,¨
J

V.&

ÛÜÄFú*@]Š%ÀÁ,Ÿï
ŽËU˜™
[J]
$%ŠP²Ê,
,2012,29(5):400
[23] 
®®

¤w

ZàP

„

(;-+±x²Š#jÀ

Ÿ
ïŽFúÉʎ˜™
[J]
ò©.-.
,1999,19(3):40
[24] 




±vI

„

ÛÜw±x²Š#jÀ

ŸïŽ
FúÉÊ
[J]
ò©.-.
,2003,23(2):49
[25] 
¶&

µ²

P$ï

·òGÑ-+±x²Š#jÀ

Ÿï
ŽFúÉÊ
[J]
$,Ú,ªœ,È
,2006,17(4):258
[26] 
FW



“—

„

…VW[x¦ïŽöÖ¾ÀÉʘ™
·618·
\ 


$,¾¿ÀÁ,Ž˜™¼½
[J]
$,ªœ
,2013,4(3):33
[27] 
*CQ

ۋ&

ÛyÂ

„

Û7ì

wÛì

A‹<ËÛ
Üız7{%À¥¬Á,ŽŽöÖKÀÉÊ
[J]
¡SI
ÙF_-.
,2013,21(30):3247
[28] 
¨Á5

‚µ

‚.9

„

©C<$bc•_‡ËÌ©
.°Â˜™¼½
[J]
$%ŠP²Ê,-.
,2003,20(2):
120
[29] BeatieKD,RoufR,MayTW,etalAntibacterialmetabolites
fromAustralianmacrofungifromthegenusCortinarius[J].Phyto
chemistry,2010,71(8/9):948.
[30] 
1Ó|

槢

¿À¥¬Á,ÂÖÌõKô|˜™¼½
[J]
$%¾©ì-.
,2007,32(4):211
[31] 
¨å

®¦º

Ûܪ[
ŸïFúÉʎ
˜™
[J]
$%ò©.?-.
,1998,10(2):80
[32] 
®}

*¸5

®ºí

„

³Ä©±w%À‘²~%ÀŽ
ÉÊfô
[J]
oΆ)k
,2011,27(4):888
[33] 
Ñ

{óôŒl©,ô|Žx#‹©,±ú’ì$°
Ž%&
[J]
%ÖA
·
$A$,‡
,1999,21(3):36
[34] 
®¸}

ɀ

1³‚

„

B/9ƒ¯9±óÀŽöÖ
¾À°ÂË:Æю%&
[J]
°ŠA,
,2006,34(9):596
[35] 
Ä%I

„W

,‡Ö

„¹‰öÖ¾XÀ°Â˜™
[J]
$
,Ú,ªœ,È
,2011,22(4):382
[36] 
sڅ

*ñÓ

…~—

„

FJ“챿À£®{
DNA
Ž’ñªÁ¾Éʘ™
[J]
$%,È@†
,2013,30(3):61
[37] TsuchiyaH,IinumaMREductionofmembranefluiditybyanti
bacterialsophoraflavanoneGisolatedfromSophoraexigua[J]
Phytomedicine,2000,7(2):161
[38] 
¨\ž

BC1Çì

±Áë^K¹ÑÛ>ûüóÀÖÌ
Ÿ^ŽKôÉÊ
[D]
w7

R-…éw
,2014
[39] AmayaS,PereiraJA,BorkoskySA,etal.Inhibitionofquorum
sensinginPseudomonasaeruginosabysesquiterpenelactones[J]
Phytomedicine,2012,19(13):1173.
[40] OMoyosoluwa,GWKaatz,GSimonAntibacterialandresistance
modifyingactivityofRosmarinusofficinalis[J]Phytochemistry,
2004,65(24):3249
[41] 
‡ºY

Ù¹ÃÄ#öË̪ÌØ$,#öèñ²Ê±¿À
©.íKôÉʎ˜™
[D]
ýº

ýº$A,w
,2011
[42] 
±i

±:-

ˆ•k

„

$,#ö·c¸c±*@]Š%
ÀŽÁ,»¼ÉÊ
[J]
$%œ,Ȫ‘
,2015,20
(2):155
[43] 
±¶‰

çøw

$,#•rð•±w[À

ŸïFú
Éʎ˜™
[J]
TÊ,.ªœ
,2013,16(12):1147
[44] 
ŠÕm

ó

!l

„

NÜâå¦ï¾À¾?SÉʎT
U˜™
[J]
5qA,
,2012,16(11):1572
[45] 
*ÊI
,¨
¹.

tõï

L/$,ô|±Áë^K¹ÑÛ>û
üóÀJàÂTU˜™
[J]
T2$A-.
,2007,29(10):6
[46] 
®®

¤w

µ²

„

ÑÒc*n|±²~%À
P29
Ž

Ÿ
ïö8öÖFúÉʎTU˜™
[J]
·$‹A&wk

2010,26(2):139
[47] 
¤w

¤Õ

µ²

„

Ë$Ñ-+±x²Š#jÀ
PA11
Ž

Ÿïö8ÖFúÉÊ
[J]
§¹wk


,2003,29
(2):170
[48] 
Ñ©í

Gw¹

¸

„

@/\.Ñ-.±w%ÀŽK
ÀWy˜™
[J]
¬Œ©?k
,2012,33(6):72
[49] 
®,
¤w¸

*»F

„

$,,,Æw±
(MRSA)β8À
(•¾©ìÁ,Ž»¼ÉÊ
[J]
Av²
,2011(7):
3519
[50] 
¨å

®¦º

ÛܑÛ7±w%À

ŸïFúÉʎT
U˜™
[J]
E5A}k
,1998,16(1/2):21
[51] 
*Ú5

$T,Ñ-.±,/\.?/ÀŽ¾À°Â˜™
[D]
ñp

5qÜ)w
,2002
[52] 
¨È

oæÚ

éCÂ

H_‡Ë,ÈÉʘ™¼½
[J]
ŠPA,m©
,2013,29(3):386
[53] 
®·

èéêë챎•,.¾·E;À°ÂwWÉʎ
TU˜™
[D]


à9w
,2007
[54] 
®.

#%š



„
20
/wåâS$T,öÖ¾ÑÛ>
ûüóÀ°ÂLM
[J]
$%ààô-.
,2013,12(5):
321
[55] 
wYí

^

±‘

„

ìT]Ñ-.¾•ËKÀÉÊT
U˜™
[J]
O£%A%,
,2008,19(7):1603
[56] BaeH,KimR,KimY,etal.EfectsofSchisandrachinensis
Bailon(Schizandraceae)onlipopolysaccharideinducedlungin
flammationinmice[J]JEthnopharmacol,2012,142(1):41
[57] 
±’w

O³?

t±Ú

„

M]WT*n|±²~%À

ŸïöÖFúÉʎTU˜™
[J]
…2A}k
,2003,
18(3):1
[58] 
¶&

µ²

P$ï

·òGÑ-+±x²Š#jÀ

Ÿï
ŽFúÉÊ
[J]
$,Ú,ªœ,È
,2006,17(4):258
[59] CechNB,JunioHA,AckermannLW,etalQuorumquench
ingandantimicrobialactivityofgoldenseal(Hydrastiscanaden
sis)againstmethicilinresistantStaphylococcusaureus(MRSA)
[J]PlantaMed,2012,78(14):1556
[60] 
1‚“

10

tW

„

†íÑ-.±Ü‹Ç/%ÀŽKÀ
fȘ™
[J]
W&
,2012,33(1):103
[61] CoumansJV,ReinhardtMK,LiebermanIHKyphoplastyfor
vertebralcompressionfractures:1yearclinicaloutcomesfroma
prospectivestudy[J]JNeurosurg,2003,99(1):44.
[62] 
*&

wr[

Ò©

„

O°um‡öÖKÀÉʎ
˜™
[J]
$%TU”
,2011,15(8):1273
[63] 
tžè

!é•

犖

„

‘PÑ-.KÀ°ÂËÌKÀ
fȎ˜™
[J]
W&(
,2009,34(5):233
[64] 
—‘[

Dà¾ÀwJ°Â.ŸŽ×‡=Ë©.°Â˜
™
[D]
¬ù

©LwAw
,2013
[65] 
õõC

…†BW‡Ñ-‡=˱¿>\óÀKÀ°Â(
×
[D]
ýº

§¹Ü)w
,2014
[66] 
®}

*¸5

®ºí

„

³Ä©±w%À‘²~%ÀŽ
ÉÊfô
[J]
oΆ)k
,2011,27(4):888
[67] 
­H§

!XÔ

:.l

QRãvŽ¾À°Â˜™
[J]
5
qÜ)&
,2012,40(10):5976

€-0
 
Š‹Œ

·718·