免费文献传递   相关文献

Study on allergenicity of chlorogenic acid in Qingkailing injection

清开灵注射液中绿原酸致敏性的研究



全 文 :ó—f?HIrgÈ@@B›[ƒ„
.ó;
!
#
.cˆ
#
dt)
#
gl
#
mc`
#
Ei2
!
8;8HI¯J H¯Ãé8ê
#
è•
PMM[MM
$
‰;
%!

&
[\ó—f?HIrgÈ@
$G#&/%/*()G$G5!=%
[@B›

‹Œ
.
כ¨¡BG¡B§¨…”
!
[=
A
7($*&(
AGQE[Éê]D!
a%QrÙ?
!:*-!:*?!:*Ñ
:B;^
[Z·D!

=
[@B›

Ž
.=
è“
³
7($*&(
AGQEäãÒâ[Éê]D!
QrÙ?
!:*-!:*?!:*Ñ
:B;^
[Z·ÙèD

.=
£“³AGQ
Eã.u[¨¡BG¡B;
$
‘’
%!
gÈ@
&
ó—f?HI
&
¡B;&
¨¡B;$
8‚$f
%!WMPPMOPMMM^
$
“”Eq
%!
­æ
)
iDŠÇ†Ü
*
ö÷iD«u
$WMM_c+M_OMP;
MML;MMN%
$
ƒ€>„
%!
!
‡¤­
!
!ƒ„ˆ
!
‚&±×rÇ?HIY:;\ƒ
„
!@(&.$MPM%X^MP^^PP;OOW^!-;I$&. #`*EXNhN\2/IgG/I
!!
gÈ@
$G#&/%/*()G$G5!=%
õ| èi&ã
ÌW›[66ZÌY
!
‚&Œ]tÀT
#
çZ‡r
Çr
!
è?6\[Ç¥E›
!
ûÀ—
#
ÀÐv
#
AÛ¬
Â
#
Àæ$
#
QM
#
Qœ
#
óMl]sÑkèré
6ËFã‡

,(êõê™À—Öv
#
LXrÚÇ
[‚&èéÚ6
!
mú,EêԛԷ[!À
!
ìZ
7
!
-Põ| *ð[@BÌY

û·‘‹
=
[
¬+
#
‰?
=
[>O›
!
õƒZè
=
rNJ
ǑSTA[D

胄¼.
!
cZrÇ?H
Û[Y:;$$5D(%0(5%4*%($G2/)0! =R3%
i
=
“³[Dì;\è‰
P(

ó—f?HIr[
tÀTÑçZŒZè
=!
ê>T„ó—f?H
Ir
=
[@B›D
!
¤ƒ„×›¨¡BG¡
B§¨…”
!
[7($*&(
AGQE[Éê]GQ
rj‰ã\G¹˜!ÀZ·[D!
•]ó—
f?HI[ü5ƒ„rê
=
[AKi)µo§
¨G¥,¦)

!
ÁÂ
! !`
ǎGçÛ
!
gÈ@
!
ë)ÉìãÌ÷Ñè#
–$
!
q
_Ni!
Ãf
Bd1M_MNWO!
â›h›ã¥¥
l±Ú
MgWi
hijk^lmníHp@q
$
È
¬
;NM%!
Ǜ¶
!

a(&5)*
–$ãä
!
Ãf
T-XPWMX=!
͛7±Ú
Pi
Äó„t
$
¡U
%!1*;
I$
–$
!
Ãf
MWXCL^^N!
â›h›ã¥¥l±Ú
PMi
yM
=
[ó—f?HI
!
6îǗè#–
$µo
!
Ãf
M_M_W_^P
ó—f?HI
!
6îǗ
è#–$ãä
!
Ãf
MNM_WWPP
AÙ?
-B:1=
çÛ
s
$
Ãf
PWPWMNPP%!
QEÙ?
!:*-!:*?!:*G
:B;^ -B:1=
çÛs
$
Ãf¦5ê
MOPWM_MW!
MOP^LLWW! MOPOXOWP! MOPWLWXP! MOPO[PX^!
MOPLXWMO%
Œ]t­
3$U5b/B$b
µo

! #`
ÊÌ
!7($*&(
A
!
þi
$PW jMgL% V*!
u©ª
›
!
«×ç]ö]ð§¨ÊÌrßµo
!
ÊÌÄÅÆ
f
1+C$
«
%WMM[;MMM^
QE
!
þi
WLM kOMM *!
©
#
u¿ÿ
!
øù¢8ï}mnȨ̂¨rßµo
!
ÊÌ-*Æf
1+C$
ù
%WMM_;MMP^
! $`
ßà
!=>?-B=9;LNMO
.¯X·?H´
$
_
&>°.ZáÝè#–$
% 7:T;3=ROlÊuÀß
$
t­d9–$
%
#
…”
# !`

!
¨¡Bç¨
.
V
7($*&(
A‰e6ê
L
Ù
!
6uêȬ
;NM
Ù
#
㥥lÙ
#
gÈ@Ù
#
ó—
f?HIÙGyM
=
[ó—f?HIÙ
!

O
#

¡Bç¨
.
VQE‰e6ê
L
Ù
!
6uêĄt
Ù
#
㥥lÙ
#
gÈ@Ù
#
ó—f?HIÙGyM
=
[ó—f?HIÙ
!

PM
#

# #`
§¨¡P
!
¨¡B§¨
.
¿Ù
7($*&(
Ah³
‚
L IB/I)
QP
´L?Hj\ÇI
!
ÛÇ·ê
XgX[ IB/V*
QP
$
jΝâãÚ±›ÇJDÛ·[
PM
ýÛ·
%
d}[\ÛÇh
#
¾¿ÙA[Éê]D!
>ê)àë[$iF6
&
ÛÇhGÛǾ©#‚
Q
!
6ŸQó
!
a%Ù?l…

ê)
7($*&(
A[àë
GQrÙ?l…[
7($*&(
A[@B›
$
¼
P!W%
/M[NP/
{
OX
ï{
P^
•
WMPP
÷
[
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&gOX! :004(!P^
94&A! WMPP
¼P!
AÉêEúF¶À+
;\1 ;\àë
M
,Eú;P !
ðÁY>
!
˽¾¿
!
ïð
#
‚»
!
Ø6ÊÌH5KR
J
O I)
~LÊ
W !
OØÊÌKR_£àë
O
5_
!
ðÁY>t}7
š ¡
O I)
O !
Ø6ÊÌJOØÊÌKR˽¾¿
#
¿ë
#
Ž~ñî
áQ
^ !
Ø6ÊÌJOØÊÌKRÙÆ
#
åß
#
ÇÈ
#
òºŽ

#
ÊÌÛY>
L !
Ø6ÊÌJOØÊÌKRùú
#
©ª
#
D6ÉÊ%
#
9678Y9
#
,N
#
w:
#

¼
W!
¨¡B;\[ÔÀ+
EúÉê6_ Ù?3=
Zi
[Ô0•
nP M kOM

!
P kW OP kLM

!
W kO LP kPMM
ݛ
!
oO oPMM
1ݛ
¡B§¨
.
ê)O.‚Ê¡Bç¨[…”
!

§¨{
P!O!L
86u¿ÙQEËxy?H@B
ÇÌ
O
5
!
Û·ê
OgL IB/V*
QP
$
jΝâãÚ±
›ÇJDÛ·[
L
ýÛ·
%&
§¨{
P^
8@B
[
W
ýÛ·QɁ‚?H
!
VÛÇ

[\ÛÇ
hGÛǾ¿ÙQE[;\GàëKR
#
LÊ7
š

VÛǾ
PM I)$
KRv‘
!
KÓ×Q
%!
ß
×Q
!
6ŸQó
!
’“
-B:1=
çÛs%QóÙ
?
!:*-!:*?!:*[ÇÌAQE[@

$
¼
O!^%
¼
O!
QE¡B;\Éê]F6À+
F6 ¼R F6 ¼R F6 ¼R
M
»ú
! [
ËG`ñ
P^
DìYR
P
Y>=
N

!! PL
Š‹
!!
W

! _

!! PX
÷Œ
!!
O

! PM
م
!! P[
ùú
!!
^
‚»
! PP
ËG†x
PN
óK
!!
L
ïð
! PW

!! P_
¾}ËG
X
òó
! PO
̉
!! WM

!!
# $`
ã.]…”
!
.·™Â %
j#
¼½
!
ٚ‘
’×›HY—…C6‹…”
!
…C㛛
1245()2;
>(EI$);C(4&0

!
…CYã›
@$I#$)(f0@W
a
¨
!$nMgML
êèã.]@Ø

¼
^!
¡B;\Éê]FGÀ+
àëU6 ;\1 [Ô0•
M Q

!!
P k^ m
Ðݛ
!
P kPM
ݛ
!!
P kP_
# 1ݛ
!
WM
$ Û1ݛ
$

$ !`=
A
7($*&(
A¨¡B;\ç¨
!
Ȭ
;NM
ÛǾ
!
ÊÌKR.u[¨¡B;!
Ù?.u
3=
$ oPMMi% !
kp¨¡B;\1ݛ
&
yM
=
[ó—f?HIÙKR¨¡B;\GÙ?3
=
!
kp¨¡B;\*ðݛ!
&
ó—f?H
IÙKR¨¡B;#
Ù?3=
!
kp¨¡B;
\ݛ!
&=
Ù[Éê]GÙ?Œ,.uD
!
ê~›
&
¼.
=
Yõó—f?HI[‚&@
BÌY
$
¼
L%
¼
L!=
A
7($*&(
A¨¡B;\Éê]G
Ù?[st
$
%
j#!%YO%
Ùu Éê]D\ Ù?3=
Zi
[Ô0•
㥥l
M jM QPXg[X jO^gNM

!
Ȭ
;NM ^ jPg[O WWLg^O jW^Wg^[
1ݛ
= M jM WNgPO jPOgMX

!
y
=
ó—f
PgOO jWgOP ^PgN^ j^gP[

!
ó—f
PgX[ jWgMN L^gM[ jPWgW^
ݛ
!
!!
?
.
@B›[ÔÀ+
!
Éêݛ
. oW!

.P kW&
¹˜ÌYÝ
›
.oLMi!

.OMi kLMi
$ #`=
AQE¡B;\ç¨
!
VÛǾ
!
Ą
tÙQEKR2iÉêEú
$X
#v‘
%!
Ù?
!:*-!
:*?!:*Z·Œu¡3=
$$nMgMP
J
$nMgML%!
šÄ[Ôê1ݛ

ó—f?HIÙG
yM
=
[ó—f?HI[QEÉêè.uEú
$$nMgMP%&
ó—f?HIÙ[Ù?
!-8!:B;^

u¡3=
&
yM
=
[ó—f?HIÙ#è
:*-
[
Z·u¡3=
$$nMgML
J
$nMgMP%
yM
=
[
ó—f?HIÑó—f?HIٚÄ[Ôêݛ

=
Ù[Éê,D!
Ù?G
:*-
‡D\Y.u
!
š
Ä[Ôê~›
$
¼
X%
%
†,
x•;
!
‰
=
õ)õ@BÈ
!
]ÑsŒ]
ôéj;[
W
 [-

A
=
@B›[ƒ„
!
­®
/P[NP/
{
OX
ï{
P^
•
WMPP
÷
[
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&gOX! :004(!P^
94&A! WMPP
!!
¼
X!=
AQE¡B;\§¨ÉêD\ÑQã\!À[st
$
%
j#!%YN%
Ùu
Éê]
;\1
Qã\%Ô
Ù?
Z
!
*/B
QP
:*-ZI*/B
QP
:*?Z*/B
QP
:*QP
-8Z
!
*/B
QP
:B;^Z)*/B
QP

㥥l
M jM LgWW j^gLX MgWM jMgMO PgLO jMgW[ NgXN jPgW^ MgWP jMgPP P_gLX jPNgMM

!!
Ąt
Og[L jMg^X
W%
POgP^ jPg[^
W%
MgW[ jMgMW
W%
Pg_[ jMgW_
W%
PMgPL jPgPL
P%
MgO[ jMgMX
W%
LWg^P jNgO_
W%
Û1ݛ
= M jM LgO^ jWg_L MgP_ jMgMO Pg^^ jMgWP NgPN jMg_P MgWM jMgMX PNgN[ jPMgXW

!!
y
=
ó—f PgWL jPgO_
W%
[gPX jWgXM
MgWO jMgMO
P%
Pg[L jMgW[ _g^O jPgMO MgW^ jMgMX WXgMP jPMgM_
ݛ
!!
ó—f PgWL jPgO_
W%
_g[[ jOg_^
W%
MgWWW jMgM^ PgXO jMgW^ Ng_[ jMg_X
MgOM jMgM_
P%
O[g[L jPXgX_
P%
ݛ
!!
!!
?
.
i㥥lّ’
P%
$nMgML!
W%
$nMgMP
ƒ„®r]
WM
…ö
XM
÷ô
!
aõD[
J%((5I$)
ƒ
„6ÙÑt­[
B$A2/)
ƒ„6ÙA
=
[@B›Q
É>ƒ„
!
>¼>FJ,7
!

=
õ)ê@B
È&Kj;[0,
.
hF(ê
=
õ@BÈ
!
>é%
ª@BeÜõEêÿÀÈ[
=
Qбþ~i„t
Y0Ä
!
fäã@BW›
&
f¾F(ê
=
Yõ@B
È
!
)»@B[ÌYõ
=
öµÌr[D6ZÌY

=
õ)ê@BÈ:,/š0,
!
‚&õ]3çÌ
[qÑ稅”YZó@b…0•Y|@
W;^(

¾AjD,Q|D1l
!
­~”÷+èj‰[
e(1l

èZ]F(ê
=
õ| ÿÀÈ
!
¤.
$õ| úû[@BÌY
!
EêÿÀÈ[
=
¤.
>Yw蹘ț
!
×iL·[w蹘ț[¶
þ„t0ÄڝOÀÈ
!
±f¼RK¹˜È›

›

=
[rÇÁÜÚ[rÇ?HÛléäè@B
[¯-
!
ª@BE›õm¡
=
i„tY_[&s
@0Ä
!
Yj§1_
=
“³[õ
:*-
}ó[¡B
;
>Æ.
=
iD6Z„t­·0ľ*Ü
Ýw蹘›[
=
OÀÈ
!
g„äã¡B;!
Yj
=
õeþ?HZ
=
rÇ?HÛ¾äã¡B
;\[ÈYg|
L;[(

|¨]F(ê
!
Z
=
[r
Ç?Hۓ³¡B;\[1lr
!
™(êp5›Ç
Óã¡B
!
è@B¡P
!
Vi75͛۷
#
<
u¡j‰
!
 *gYõ2Å@Ø_[¡B;$:*-
}ó[ÀÈÀþ;%!
f\6PꨡB;

ÛQE‚?HÚ±JDÛ·
PM
ý[tÀT
9µ#Ì?HI
$

=
.
%!
QE£KR¡B;!
fZ諜
#
„t
#
ŸIY‡£Y[tÀTöµ#Ì
?HI=“³¨¡B;N(

÷7݇ƒ„¼.
!
=
µ#ÌKR[¡B;\i€qµ#ÌrŒ]
[D6ZÙ63šj‰
!
i
=
G66Z¨ßÌ,
‰
_(
!
>]DE
#
6E
#
QE‡Z ÊÌ
#
E ÊÌ
š,Ê˽¡Bç¨
$8=%
Œu½?H›bcdE
ê|j…“³Y:;\[*g›D
=
¤
.
PM(

胄¼.
!

=
[ó—f?HI[@
B›i
=
[qè‰
.
€q
=
µ#Ì[@B›
iªr[D6ZÌY3šj‰
!
i
=
¤.Ñ66
ZÌYè‰F
PP(

¤ƒ„r
!
yM
=
[ó—f
?HI[¨¡B;\ê*ðݛ!
!
f¡B;KRݛ!
!
ó—f?HI[¨¡BG¡B;ŒKRݛ!
!
f
=
£KR¨¡BG¡B;
YjEF(ê
!=
Yõó—f?HI“³¡B;[‚&Y—
!
ó—f?HIEê|rÇj…“³
Y:;\[*g›D
=!
i:à[ƒ„0•j
ß
PM(

]Aó—f?HIQÉ>O›ÖFG7
!
*
AK?HÛrRèZ·[
=!
ì\q\yMD6
Z£Y
!
/Aâã›Ç>O

$
•–—˜
%
P (!

!
@AB
!
CDŽ
FNON
.rÇ?HIY:;\6‹
9(F
§›ÇÌiâã
!WMM[!PM$^%.WWNF
W (!J%((5I$) 1 TF#&/%/*()G$G5. $) $&(%*() ) *%(() G/6()
b($) 9(F>$24%(!P_XP!P_W. W^PF
O (!7%$)$R1! C%4U(A9! J%((5I$) 1 T!(2$&F#&/%/*()G$G5.
64%2#(%(D5()G(6/%20$)2*()G$)5 $)2*()G$G2D2A9(F>$;
24%(!P_XL! WM[!PPLLF
^ (!B$A2/) BBF>/)5640b&($&(%*()GG/)2$I)$)20/&$2(5 6%/I
0$IU&(0/6G#&/%/*()G$G5 G$40)*$&(%*G%($G2/). U4%(G#&/%/;
*()G$G5 )/2$) $&(%*() 9(F=&(%*A! P_XX! L$L%.WXNF
L (!
X¹K
!

!

!
‡
F
YZ­·£gÈ@OÀÈ[¹˜È
›ƒ„
9(F
r­rÇ£¤
!WMPM!OL$WM%.W[LXF
X (!
ú­:
!
¹“û
!
¹gß
!
‡
F
gÈ@OÀÈ[ÜÝGÕÔ
9(F
Öツ
!WMMN!O[$X%.X_MF
[ (!
‰ß
!

!
‡Jü
F
gÈ@±NÀÈ[ÄÚG;\Fq[C
9(F
r­rÇ£¤
!WMM_!O^$PL%.P_MXF
N (!
‡ýÎ
!
-¸þ
F
bcd?HÛY:;\[ÈYGª¾2
9(F
sÿ‡çÇö]
!WMML!WN$O%.NXF
_ (!
÷7Ý
!
-.Î
!
ô’ø
!
‡
F
tÀT9µ#Ìiöµ#Ì?
HI[‚ÊO.¡B稃„
9(F
7!­ç­Ç
!WMMN!P_
/W[NP/
{
OX
ï{
P^
•
WMPP
÷
[
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&gOX! :004(!P^
94&A! WMPP
$PW%.WN^[F
PM(!

!
w
!
‰D#
!
‡
F
gÈ@AÊÌ[@B›ƒ„
9(F
Î
)Ç]£¤
!WMM_!W^$W%. PNPF
PP(!
[Yú
!
?Î$
!
‰D#
!
‡
F
gÈ@@B›[šÄƒ„iF
G
9(F
r­rÇ£¤
! WMPM!OL$W^%.OOL[F
=DIHF BC/1AGUAC0T0DF BLTE1BGBUAC0T/T0H0CZ0CU[/010CU 0CWATD0BC
a=>?c#*4/
!
! a=>?R$)]$/! d,d/4#4$! 1,:d4! ,:.$6()*! c.=>?<(A4
$+,-(&.-%!/01-#-/(23 4-%!-(! 43&%/ 52/6-.7)843&%-#-9-6&2/0:2&%2-#! ;-&<&%= PMM[MM! 43&%/%
6NKDG/TD(8NWATD0RA. @//b0(%D(2#($&(%*()G2A/6G#&/%/*()G$G5 $=% ) e)*V$&)*)H(G2/)F>ADEBH. =E$0$5;
I)02%$2(5 2/7($*&(5/*02#%/4*# )2%$D()/40)H(G2/)! $)5 /) (KU(%I()2$&$&(%*G0()02`$2/) /6*4)($U*0! 2E$02#%/4*# )2%$;
U(%2/)($&$)5 )2%$D()/40)H(G2/)F@#(b(#$D/%$&G#$)*(0/67($*&(5/*0$)5 *4)($U*0E(%(/b0(%D(5! $)5 G#$)*(0/62#(G/)2()2
/6#02$I)(! :*-! :*?! :*U#A&$G2/5 $)5 $&(%*GI(2#/50F:AKI1D. @#(%(E(%()/2AUG$&b(#$D/%$&G#$)*(0$)5 )G%($0(I()2/62#(G/)2()2/6#02$I)(! :*-!
:*?! :*XAF VBGHK(!G#&/%/*()G$G5& e)*V$&)*)H(G2/)0& $&(%*G%($G2/)& $)$U#A&$G2/5 %($G2/)
HB0.!+]%#)QTWT..#+!!!%+(
$
…†$Q
!
‡ˆˆ
%
›
!!
œ
ö]KÂΝ
WMPP
÷
O
²KÂ>]r­ÇŽãÌ܎aÔ²‰% ]^‚W[
,
r­ÇÁÀ+M
%
-
EF]­æ²ŽÇŽR¼·¥2[DNÝtÑO­¿R
#
lb(
#
û&SÇa²[U۱Ī
!
±
WMM^
÷—˜
!
H®ž¥ñÂÇÒ
#
ØÀ+
#
Q…À+‡D·™Â
!
ñ7
X
÷
!
QÉ>M@9
!
Wz>
Ф¿î
#
§›[rÇÁÀ+aU«—NwÆ

6ÆÐH%>
^ [MM
ç ÇÁ
!
þG
LOM
ö
!
~()Ç
ÁM
#
öM
#
c*öM
#
¨u
$
ÊÌ
#
ÉÌJËÌ
%
ÈÊÉÌr7M
#
ÈÊÉÌc*]M
#
ǛØIGKև

Wzy.
!
~§›
!
õ–—
#
çðrçÇö÷NEF‘Ý[
#
¿î[ÇÁÀ+aU«—NwÆ

Îθ
#
g

#
ŠÎÆhGç]«—hèj

ÔG
W_N
8

./
.MPM;X^MO^XMP!X^MP_MOP&
Q%
.
øùSúclêø
þ
PX
fö]KÂÎ
$PMM[P[%&
·F±
.
¬YG
&
#]ÿmž?.²pdÆ[ÆM
#
n(
#
·F./
#
õ)&
o‡

/O[NP/
{
OX
ï{
P^
•
WMPP
÷
[
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&gOX! :004(!P^
94&A! WMPP