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期 刊 ：中国中药杂志 2008年 33卷 16期 页码：2033.

关键词：葛根素；维拉帕米；药动学；

Keywords:puerarin, verapamil, pharmacokinetics,

摘 要 ：目的：研究葛根素在大鼠体内的药动学过程以及维拉帕米对葛根素在大鼠体内药动学过程的影响。方法：对大鼠分别单独静注、单独口服葛根素溶液，联合静注、口服葛根素和维拉帕米溶液，采用高效液相色谱法测定葛根素在大鼠体内的血药浓度。结果：注射合用后，维拉帕米在低剂量时(0.5 μg·g^-1)对葛根素的药动学过程无显著性影响，但在高剂量时(2.5 μg·g^-1)有显著性影响(P<0.05)。口服合用后，维拉帕米对葛根素的药动学过程有显著性影响(P<0.05)。结论：葛根素与维拉帕米合用时，在一定浓度范围内，维拉帕米可抑制葛根素从大鼠体内的消除；二者合并用药时应对葛根素进行临床给药监测。

Abstract:Objective: To investigate the effect of verapamil on the pharmacokinetics of puerarin in rats. Method: Puerarin with or without verapamil was administered intravenously or orally to rats. The concentration of puerarin in serum was determined by HPLC. Result: No significant difference was found between the control and 0.5 μg·g^-1 verapamil combined groups for intravenous administration, and there was significant difference between the control and 2.5 μg·g^-1 verapamil combined groups (P<0.05). When puerarin was administered orally with verapamil, significant difference was found between the control and combined groups (P<0.05). Conclusion: Verapamil inhibited puerarin metabolism when puerarin was coadministered with verapamil, so it is necessary to change the therapeutic dose of puerarin.

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