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期 刊 ：中国中药杂志 1992年 17卷 11期 页码：680.

关键词：川芎嗪；阿魏酸；主动脉；心脏；血液粘度；

Keywords:tetramethylpyrazine, ferulic acid, aorta, heart, blood viscosity,

摘 要 ：运用q值计算方法评价川芎嗪和阿魏酸的合并效应。实验发现两药合用对兔和大鼠离体主动脉痉挛性收缩的缓解作用、增加豚鼠心脏灌流量及降低大鼠全血粘度等作用与单用该两药相比呈协同;而对小鼠急性毒性,合用时毒性为拮抗。

Abstract:The experiments showed that both tetramethylpyrazine and ferulic acid relaxed the norepinephrine-induced spasmodic contraction of rabbit and rat aorta strips, increased the coronary flow of isolated guinea pig hearts and reduced the whole blood viscosity in rats. Evaluated with Burgi‘s equation, the combined effect of these 2 drugs was obviously potentiated, but the combined acute toxicity in mice was greatly reduced.

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