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作 者 ：郭东杰;顾成波;*;祖元刚;李旺;赵修华;

期 刊 ：植物研究 2014年 34卷 4期 页码：567-571

关键词：牡荆苷；纳米混悬剂；制备；表征；

Keywords:vitexin, nanosuspension, preparation, characterization,

摘 要 ：为提高牡荆苷的水溶性和体外溶出度，采用反溶剂结合高压均质法制备了牡荆苷纳米混悬液及其冻干制剂，并对其理化性质进行表征及体外溶出度分析。激光粒度仪测得牡荆苷纳米混悬剂冻干粉复溶后平均粒径为(135.7±10) nm，Zeta电位为(-17.05±1.40) mV，SEM扫描结果显示牡荆苷纳米粒子以近球形形态存在，X射线衍射、差示扫描量热法及红外光谱证实牡荆苷纳米混悬剂冻干粉中牡荆苷纳米粒化学性质没有改变。牡荆苷纳米混悬液冻干粉的体外溶出度与原药相比显著提高，5 min内其体外溶出量为药物原药的4.5倍。

Abstract:For improving the water solubility and in vitro dissolution rate of vitexin, we prepared vitexin nanosuspension by recrystallization method combined with high pressure homogenization, and characterized the physiochemicalproperties of vitexin nanosuspension frozen powder and in vitro release behavior. The mean particle size and Zeta potential of vitexin nanosuspension after reconstituting were (135.7±10) nm and (-17.05±1.40) mV, respectively. The morphology of vitexin nanoparticles was spherical in shape by scanning electron microscopy(SEM). By XRD, DSC and FT-IR, the chemical properties of vitexin nanoparticles were unchanged when compared with unprocessed vitexin. The dissolution rate of vitexin nanosuspension frozen powder were significantly enhanced, and in vitro cumulative release from the freeze dried nanosuspension were 4.5 times greater than that of pure drug in 5 min.

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