免费文献传递   相关文献

Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound Hongcao for injection by UPLC-MS/MS

UPLC-MS/MS研究注射用复方荭草中原儿茶酸、异荭草素和野黄芩苷的大鼠组织分布



全 文 :,8B;<1Z<1
ƒ„?t›j…ŒFrȉÈ@
#
EŒF—ÑC;Éd[¸¹ÙÊ6G

#
E‘Þ
#
¬
#
`
#

#
.:
!
!
s&I¯K L¯K
#
sW s&
LLMMM^
$
;
%!

&
noZ7%Ô¸¹°u?tj…ŒF¾ÙÊàVrȉÈ@
#
EŒF—ÑC;ÉdZ·[
,8B;<1Z<1
6‹…”
!
ƒ„
O
 !ÀÚ6]¸¹þ~[6G¯H

ƒ„
.
»›
=G]42A,8B

!7-.
PN
V
$WfP IIhLM II!Pf[
!
I!
š­
a$2(%0
–$
%!
ŸÊjꢠ
;MfPj
¯@¤Ûzü
!
ŸLê
MfOL IB/I)
QP

»›.JK.q¬
$-1:%!
12…}ê™
\qL>%
$<3<%&
Ùʦ¤»›×Òa$
#
¯vwÖ¥o%Ô

…†
. O
 Ú6[n›‰F¨W
$-nMf__%!
+/
#
¥
~Ñ¥š93
#
µ#ÈHhŒ/Äã̦|[6‹&

¸¹?tj…ŒF¾È‰È@
#
EŒF—ÑC;Éd‚&6G]
°
#
r
#
߇àVr
!
]¾r6G½e

…‡
.
!ÀÚ66Gƒ„¼.
!
¸¹°uÛ?t›j…ŒF¾
!
þ~6GwèYŒ‡
[¯H
!
QŸá^ÙÊ[6GjAþ™
&
ÇÌ]þ~¿ÙÊàVoÂÖL
!
,_Ur´
&
no[…”*¯E
#
3
#
ÅLQZ7
%Ô¸¹ÙÊr[ȉÈ@
#
EŒF—ÑC;Éd

$
ˆ‰Š
%!
j…ŒF
&
ȉÈ@
&
EŒF—
&
C;Éd
&,8B;<1Z<1&
ÙÊ6G
$
8‹$f
%!WMPPMPWWMM[
$
ŒEp
%!
­æ
)
i¸ŠÇdÜ
*
ö÷i¸«u
$WMMNd+M_PMP;
MWP%&
­æléö]stuv
$OMNXMOXX%
$
Ž>
% !
!
-»5
!@(&. $ MNLP % X_MNN__!-;I$&.*AEA&*IGf(54fG)
!!
?t›j…ŒF:­Tm
$
ª«êj…Œ
F
%
Â]B;Ïó›Ç[s©_ƒÜ[rNJÇ
!
ûŒFÑo`®k
W
ZrÇËRôÜÛNރÜf
Ú
!
wè\Om²
!
UQ±è[Þg
!
Þߛ)ß
Ýß*èßQOàÆ
!
vhϝÚ-•Þßç¨

j…ŒFrZè‹@¨[ȉÈ@G;„¨[EŒ

#
C;Éd‡Ú6
P;W(
!
ȉÈ@wèu¡{Æ
ß»ÄÈ·
#
µëß»PÈgN‡Ç¥E›
O(
!
E
ŒF—h8éîd¨;„
!
wè–È#
•Ü¯ë¨
¡È\¦U›‡E›
^(
!
C;Édêç@d¨;
„
!
wèAÉßG
!
{ÆrÊuëM
!
–QË|Ú
!
–
ßë¹j‡E›
L(
!
ƒFêÜÛr[i&U›Ú
6
X;[(

¤7j…ŒFrȉÈ@
#
EŒF—ÑC
;Édê!À›Ú6
!
%Ôíj…ŒF]¸¹þ~
YZ7š-_°
#
r
#
߇™‚&Gàr[6GË
7D!
m]%½¸¹°u?tj…ŒF¾ª]Ù
Ê[6GÓë
!
êAÆÇÌÞß\›[€Oèéµ
o¦)

!
ÁÂ
!W!
ßà
!
 ëéuj{O
;
YO·›ß
$
š­
a$2(%0
–$
%!
{ONE¹
.<$00&A)K^fP&PZP
}.L
8~
$=-W^M
’¯9
;
¬™ßàè#–$
%&
Æ+
ëLqß×
$=&(*%$X^3
š­
7(GVI$) /4&2(%
–
$
%&
ŒÏ<¢gì
$<@>;WNMMR
8xt¯òÛ;
ßàè#–$
%&
*àëLa$×
$J1.;W=
þ;
×Òè#–$
%
!W#
Ç|içÛ
!
ȉÈ@
$
Ãf
NM_;WMMPMW%!
C;Éd
$
Ãf
NNM;WMMMMP%
ÑGê—
$
Ãf
M[LW;
_XML%
A“|Œplr­Ç|ãÌÜ|`Ô²
&
E
ŒF—A“|ûB;RrÇÏóǃ„—rßµ
#6qÜÝ
!
›¸
_NfMj&
?t›j…ŒF:
­TmûB;«/0Öè#–$µo
$
Ãf
WMM_PWWO%&
{O¯vpl8xö3{\]çÛè#
–$
&
{O¢ plr­
<(%GV
–$
&
ªççیê
6‹›

!W$
ÊÌ
!
ÉØ
a02$%
¸¹
!
q¤a›
!
þi
$WOM kWM% *!
ûB\{]iÊÌrßµo
!
Ò*Æ
f
1+C$
(
%WMMW;MMMP
#
…”
#W!
¦|H®
!a02$%
¸¹
PL
?
!

O
Ù
$L!
OM!XL I) O
7šÙ
%!
ÛÇhbE
PW #!
lûì
¤

¤°uÛj…ŒF
!
ÛÇÛ·ê
PWM
/_NPO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
I*/V*
QP

6[ÛǾ֫
!
ÖL#K¾
#
ß
#
r
#
m
#
°
#
ô
#
Ó
#
6
#
»f‡ÙÊàV

›ã¥›¤
zèÙʼTQÈG~Ì
!
³îc­

93P#
¿ÙÊ
MfL *!
>›ã¥›¤ÜÚ
WLj
a$
!
ÙÊa
$u Ù
L I)
¾
!L MMM %/I)
QP

PM I)!
6q
_4u
!QWM i
¼:AŒÝ›

#W#
A“œu[µÜ
!
93P#ȉÈ@
#
EŒF
—ÑC;ÉdA“|%·
!
¯vœ¥>ߎ¾
!
ºa
!
µÜÚY·<6[ê
MfP__ W! PfMPX!
MfXNO [ */B
QP
[A“|YÝu

Z”µÜGê—
~Àœu
!
‘&Gê—
$Mf^PO W */B
QP
%
[YÝu

#~ÀYÝu%·
!
›¯vÔŽ¾
!
µÜÚ
P I*/B
QP
[~Àœu
!
ì¼0
QWM i
AŒÝ›

#W$
{OTq
!
{OV
.a$2(%07-.
PN
V
$WfP
IIhLM II!Pf[
!
I%!
µÝ
a$2(%0S$) ?4$%5 7-.

PN
AÉV
$WfP IIhL II!Pf[
!
I%&
ŸL
MfOL IB/
I)
QP
&
V+
^L i&
å¦à+
PL i&
ŸÊj
MfPj
¯@¢ 
$=%;MfPj
¯@¤
$7%!
Ûzü
$M I)!
PMj =& MfL I)!PMj =& WfM I)!OMj =& WfL I)!
_Mj =& OfL I)!PMj =%&
å¦þUê
P
!
B
#W%
YOTq
!
»›.JK.q¬
$-1:%!
®!
.q.M
O VS!
qL¬+
PWM i &
JKÄiÏ
Ä
>
W
!
èœÛğL
XLM B/#
QP
!
èœÛÄ+
OLM i!
ÏğLê
LM B/#
QP
&
;<Ä
=%!
;<Ä
ŸL
MfPX IB/I)
QP
!
12…}ê™\qL>%
$<3<%!
YO()»®GÖ¥Ìqê
<$00BA)K
S^fP
NE¹

›Ô·6‹[qLA6[êȉ
È@
+X:PLWfN mPM_fM&
EŒF—
+X:^ ^_fW m
W__fP&
C;Éd
+X:^ XOfP mWN[fP&
Gê—
+X:
^P[fM mWX[fM
ó).M6[ê
OM!^M!OL!OM S!
;
PL!OM!OM!PL S
#W&
¦|Ö¥…”
!
#¸¹ÙÊa$_4u
OLM
!
B!
ì
PfL IB
qß!r
!
¦5aÐ
P I*/B
QP
~Àœ
u
PM
!
B!O I/&/B
QP
¯@
LM
!
B!_MM
!
B
¯v
!
—`
P I)!
 Ù
L I)!^ i! WM MMM %/I)
QP

PM I)!
#_óuìqß!r
!^N i
ªŒÄÏ­
!
¿©Ì
OMM
!
B
î˜ÛŸÊjœ¥
!
 Ù
PM I)!
—`
P I)!
^ i!WM MMM %/I)
QP

PM I)!
#_óu
!
ݛ

$

$W!
«h›‘n
!
VoçctÙÊ{Odict
ÙÊraЅ%ÌÑ~À̾&D[{Od
#
ÛÇ
¾YZ7š§%{OdåÉ·þ
!
0•¼.ÙÊr
²Z~¬›ÌYY­AÞ%ÌÑ~ÀÌ[%Ô
!
Þ
%̧|¨W

]ª´Ô[{OTqÑYOTq
ª
!
ȉÈ@
#
EŒF—
#
C;Éd
O
 Ú6G~À
Gê—[A©7š6[ê
Mf[X!PfXX!Pf_^!Pf^M
I)
6êÕ
!
Òâ{Odšd
P
=f
ct6ÙÊ
&7f
ct6a$uaÐ`ÄÀ+œuG

&f
ÛÇj…ŒF
L I)
¾6ÙÊ

d
P!
ÙÊ¿Ú6Òâ{Od
$W#
NE†n[öÜ
!
#¸¹¿ctÙÊa$u
OLM
!
B!
¦5aÐZèȉÈ@‡
O
 Ú6[`Ä
FJÀ+œu
OM
!
B!
ȉÈ@
#
EŒF—ÑC;É
d
O
 Ú6]°
#
6
#
r
#
ßÙÊFJa$ur<
6[ê
P_fM m^ XPWfN!XLf_ mPX MPXfM!WPfX m
L W^NfX )*/*
QP
!
]m
#
Ó
#
»
#
ô
#
¾ÙÊFJa$
ur<6[ê
P_fM m^ XPWfN!POMfN mPM L_PfW!
P^fO mO ^X^fP )*/*
QP

’
#W&
uª×E
!
noÀ
+†n

…%Ì[§TUi~À§TUg·
$LX
/M_PO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
=
%
ê*ôÀ
O!
¿ÌY<
$3%
êõôÀ
M
åÉû
nȘ
!
¿iF(ê
PXM
¸¹¿ÙÊa$urÈ
‰È@‡
O
 Ú6]ªn›2Ù~n›‰F¨W
!
¿
Ú6À+†nj‰F(
$-%
Œ¸
Mf__!
½Æ`%#
$BBTR%
*k
P )*/*
QP

¸¹¿ÙÊa$urÒâ
À+†nš¼
P
¼
P!
¿ÙÊa$urȉÈ@‡
O
 Ú6[ÒâÀ+†n
ÙÊ È‰È@ EŒF— C;Éd
r
! OYMfMM_ P^MpMfP_^ $-YMf___% OYMfMM^ W^MpMfPL_$-YMf___% OYMfM^N WMpPfLL $-YMf___%
m
! OYMfMPM ^MpMfP[P$-YMf__[% OYMfMML M[MpMfMLM _ $-YMf__X% OYMfMW_ XMQMfOMP $-YMf_N[%
°
! OYMfMPM PMpMfPW^ $-YMf__N% OYMfMM^ _XMpMfWNW $-YMf__M% OYMfM^[ MMpMf^X^ $-YMf__[%
»
! OYMfPP^MpMfMW^ L $-YMf___% OYMfMML XLMpMfMN[ L $-YMf___% OYMfM[M LMpPfOX $-YMf__[%
6
OYMfMMX W[MpMfMWP M $-YMf___% OYMfMML WXMpMfM[[ ^ $-YMf__N% OYMfM^^ [MpMfWLN $-YMf__X%
¾
! OYMfMPO WMpMfMMW WO $-YMf___% OYMfMMX XNMQMfMPP _ $-YMf___% OYMfMNN [MQMfM^[ N $-YMf___%
Ó
! OYMfMMN W[MpMfPNW $-YMf__N% OYMfMM^ WXMpMfMM^ XO$-YMf___% OYMfMOO WMpMfP^_ $-YMf__X%
ß
! OYMfMPP _MpMfMLP O $-YMf__M% OYMfMM^ _MMQMfPP^ $-YMf__L% OYMfML[ [MQPf^^ $-YMf__X%
ô
! OYMfMMX ^MMpMfM[M P $-YMf___% OYMfMM^ ^^MpMfMXN [ $-YMf__N% OYMfMWL OMpMf[[L $-YMf__^%
$W$
+/Ñ93
!
’
$W#
uª6[µÜȉ
È@‡
O
 Ú6ÙÊa$uë
#
r
#
Æ
O
<[Y
·Rܦ|
$c%!
7<åÉ
L
¦¤6‹
!


O 5!
>iÀ+†nZ7åÉ

ê)Î¥À+†
n.P
c
¦|[<
!
iµÜ!
V
c
¦
|[0•åÉ.P
!
&¤…”[93i+/

0•¼.ȉÈ@‡
O
 Ú6¥~Ñ¥š93
31R
Œ6
WMj!
+/2Ùê
NMf[j mPWMfMj
6êÕ
!
ȉÈ@‡
O
 Ú6[+/Ñ93
š¼
W
¼
W!
6ÙÊa$urȉÈ@‡
O
 Ú6[+/Ñ93
\ÄÌ
aÐ<
Z)*/*
QP
¥~
$&YL%
¥š
$&YO%
`%_
Z)*/*
QP
+/
Zj 31RZj
`%_
Z)*/*
QP
+/
Zj 31RZj
ȉÈ@
LXF_M LPFM_ N_FN [FN LWFOO _WFM ^FO
LPWFLM ^[LFWP _WF[ XFP ^[PFLN _WFM PMF[
^ XPWFNM ^ WPPF[L _PFO ^FW ^ POMFOW N_FL [FM
EŒF—
P_[F[M WW^FX^ PPOFX PPF[ WP^FPM PMNFO PPF^
P [[_FXM P N_MFL^ PMXFW PWFL P N[WFL_ PMLFW PMFN
PX MPXFMM PX MNOFWX PMMF^ LFW PX OLLF^L PMWFP XFO
C;Éd
X^FNM LLFN_ NXFO PMFW XWF^M _XFO POFP
LNOFWM LPMFWL N[FL NF^ LONF^^ _WFO LFW
L W^NFXM L PLLFNO _NFW XF_ L ^_XFNX PM^F[ ^F_
$W%
µ#ÈHh
!
#¸¹6ÙÊa$uë
!
r
!
Æ
O
<[Y·Rܦ|
$c%
¿
O
¦¤
!
’
$W#
uª×E
!
‘&¦|rÞ%Ì[§TU

”#6
ctÙÊa$u
!
ÂYaÀ+œuÑ~À®
!
’
#W&
uª×E

qß¾‘&_óu
!
aÐi_£j\<
[À+œuÑ~À
$
7<åÉ
O
¦¤6‹
%!

^N i
ŒÄÏ­
!
¿©Ì
OMM
!
B
î˜ÛŸÊj
ϴ
!
‘&j\§TU_

7|<[
W
 Ö¥…
”[§TU·_.Pµ#ÈHh

ȉÈ@
#

F—ÑC;Éd[µ#ÈHh6[ê
[NfLj m
_OfMj!NLfNj m__fWj![[fPj mNNf[j
~ÀÈ
Hhê
PPMfNj
$W&
Ôԛ‘n
!
’
$W#
uª6[µÜȉÈ@
‡
O
 Ú6[¸¹6ÙÊa$uë
#
r
#
Æ
O

<[Y·Rܦ|
$c%
¿
O
¦¤
!
6[]’
+
$
ª
WM i%
ªhì
X #!^ i
ª#v
N #!
:ãÔ
*
O
5
!
ËÖ¥¾å¦%Ô<
!
‘n¸¹6
ÙÊa$urȉÈ@‡
O
 Ú6]’+
!
#
v
!
j:ãTqª[Ôԛ

7|<
O
¦
¤6‹

0•Ôԛ
31R

PNf^j!
¼.Ù
Êa$r…%ÌþÔÔ

$W
¸¹þ~[ÙÊ6G0•
!
¸¹¤°u?t
/P_PO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
j…ŒF¾
!
ȉÈ@
#
EŒF—ÑC;Éd]¸¹
þ~[6Gr´šd
W
0•¼.
!
ȉÈ@Â]
Ûdz˜7š°r6Gþ™®
!
ªÿàV6G·
ae
!
µ½ïÚ6*gA°Gèþë[;ÑN
&

F—ÑC;Éd]ÙÊ6Gr´s¤jœ
!
°
#
r
#
ßrèjAþ™[6G
!
f7]¿àVÙÊ[o
·i7šÐ»j‰

d
W!
¸¹°uÛ?t›j…ŒF¾¿ÙÊr
!À›Ú6[6Gr´
%
†,
 ëéuj{O”
$,8B%
jAjÓëéu
j{O”
$.8B%

!
g¾‘&Vë[Vé
!
>7
]Vÿ[nL2Ù~VéAê–Ô
!
謝µë
ŸÊjŸL
!
g¸Ó¾5uj{O[6q
#
¦|
m·Ñ3
!
Íuj{O[6qgN&Då|Û
[ª}Ѫæ
!
a¸Qµë6‹NE[éhÑY·
!
xªiYO·›Vgu½ªx†[›g
,8B;
<1Z<1
ÏËÚêrǙÚ6j£þF6‹[
P
 
:èN[Nw
N;PM(

¤ƒ„noíj…ŒFrU›
Ú6ȉÈ@
#
EŒF—ÑC;Éd]¸¹þ~Ù
Ê6G[
,8B;<1Z<1
6‹…”
!
>AªåÉí…
”]¨Æ

ysÅL
!
«h›:
!
3ë
!
6‹éhë
$ lOfL I)Z
5
%!
%ĝ¸Ã·ã̦
|[ëm·6‹

§¨0•¼.
!
¸¹°u?tj…ŒF¾È‰
È@
#
E7F—ÑC;ÉdÖL6GD¿ÙÊàV
r
!
g¾]ÙÊàVÅLóÂ

§¨ƒ„¼.
O
 
Ú6‚&6G]°
#
rÑ߇QŸ·wc[ÙÊr
!
]°Gr[6G½ë
!
ª5êr
!
Z7]ßGÙÊr
`èþë[6G
!
ÎiÇé]ƒ„j…ŒFAº›
ß»…QÑß»=òwèþW[AÉE›*gj
‰
PP;PW(
!
f]¾rZ·½Æ
!
*gÂÚ6a›þ¸
3Ûm¡Q¾y¸

ÖÍ7š[ªx
!
ȉÈ@
#
E
7F—ÑC;Éd]¿ÙÊàVr[<ÖL{
Æ
!
¼.ÇÌ]þ~,_Ur´

$
’“”•
%
P (!
-6Ï
!
7.C
!
-»5
!
‡
f,8B
Z7%ԌFÇÁr
N
 
!ÀÚ6[Z·
9(f
r­rÇ£¤
! WMPM!OL$PO%.P[WOf
W (!
®Š‡
!
Á+8
!
-»5
!
‡
f
?t›j…ŒF
$
:­Tm
%
!
NdOƒ„
9(f
r­rÇ£¤
!WMML!OM$X%. ^^Mf
O (!
^7d
!
eN
!

!
‡
f
ȉÈ@]¸¹Q$r[ÇôÊN
]ƒ„
9(f
Rø¸]]1
.
léö]Â
! WMPM! OW $P%._Nf
^ (!
)Š€
!
½Ï
f
8é;„îdGªU›ƒ„åæ
9(f
¥h
¢Ç]]1
!WMML$WP%.POLf
L (!
x&ã
!
œ2<
!
fn§
!
‡
f
o`¢—]¸¹þ~ÇôÊN
]GÙÊ6G[ƒ„
9(f
r­rÇ£¤
! WMM[!OW $PX%.
PXNNf
X (!
Á¤â
!
®Š‡
!
-»5
!
‡
f
j…ŒFrŒFYZNÞµ#
ÌA¸¹ß»…Q[@A
9(f
r­§¨…Û]£¤
!WMMO!
PO$N%.WPf
[ (!

!
ëT
!
Án.
!
‡
f
ùjå#
;
ëéuj{O”Z7`%
ÉرQ$r[EŒF—
#
ŒF—Ño`¢—<
9(f

ÞßÇ¥]£¤
!WMM[!WO$^%.W__f
N (!
;}
!
-7û
!
â1
!
‡
f
 ëéuj{OÑYO·›]Ç
̃„¯°[\›
9(f
IO§¨’
!WMM_!WX$^%._WWf
_ (!
D
!
J.&
!
Hg
!
‡
f,8B;<1Z<1
”Z7%Ô±Q$r
±cd
3(
Ñ
3*
P
Z·GA:­TmÛ[ÇôÊN]
89
9(f
–P¸]]1
.
{]Â
! WMM_!^M$L%._PWf
PM(!
¼
!
k7§
!
¡tÉ
!
‡
f,8B
”Z7%Ôp?tÛr
X
Ú6[Z·
9(f
ÇÌ6‹£¤
!WMMN! WN$PW%.WMWPf
PP(!
½ú]
!
—D
!
-»5
!
‡
f
j…ŒF:­TmÛAŽg;§
¨›ß»=ò[AÉE
9(f
7b­{­Ç
! WMM[!PN$O%.
LO_f
PW(!
—D
!
½ú]
!
-»5
!
‡
f
?t›j…ŒF:­TmÛ
$JJ;
.%
Aþ¾ƒ—øϸ¹º›ß»…Q[AÉE›
9(f
hiÌ]i]1
.
léö]
!WMMX!W[$W%.PP[f
/W_PO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
=0.I1D/CABIKHADAG.0C/D0BCBNOGBDBT/DATEI0T/T0H! 0KBBG0ACD0C/CH
KTIDA1/G0C0CG/DD0KKIAK/NDAG/ K0CV1A0CDG/LACBIK/H.0C0KDG/D0BC
BNTB.OBICH3BCVT/B NBG0C[ATD0BCMF 9P;2->=R>=
.,=>?e/)*! d.=>?d#%/)*! d.->?B)! .-J()*! .->?.4! a=>?e/)*&)
!
$E,%..).A=%#-+#,(! 9*(#&7 ;5/,#)3.)575! 9*(#&7 LLMMM^! 3%&#%
6MKDG/TD(8M[ATD0LA. @/(02$b&0# $) ,8B;<1Z<1 I(2#/5 6/%0I4&2$)(/405(2(%I)$2/) U%/2/G$2(G#4G$G5! 0//%()2)
$)5 0G42(&$%) ) %$22004(0$62(%$0)*&()2%$D()/40$5I)02%$2/) /6/IU/4)5 ./)*G$/6/%)H(G2/)! $)5 )D(02*$2(2#(502%b4;
2/) G#$%$G2(%/62#(2#%((G/IU/4)50f>ADEBH. @#%((G/IU/4)50E(%(0I4&2$I(/40&A5(2(%I)(5 bA,8BE2# a$2(%0=G]42A,8;
B7-.
PN
G/&4I)f@#(I/b&(U#$0(! G/)002)*/6$G(2/)2%&($)5 MfPj $]4(/406/%IG$G5! E$0U%/*%$II(5 $0$&)($%*%$5;
()2f@#(6&/E%$2(E$0MfOL IB/I)
QP
f@#(G/IU/4)50E(%(/)`(5 ) 2#((&(G2%/0U%$A/)`$2/) /) 0/4%G(/62#(I$000U(G2%/I(;
2(%$)5 5(2(G2(5 ) 2#(I4&2U&(%($G2/) I/5(&f@#(2004(0$IU&(0E(%(#/I/*()$2(5 $)5 2#(040U()0/) E(%((K2%$G2(5 E2# I(2#$)/&
6/%64%2#(%40(f:AKI1D. @#(%(&$2/)0#U b(2E(() 2#(G/)G()2%$2/) $)5 2#(U($V $%($0/62#(2#%((G/IU/4)50E(%($&&)($%$-n
Mf__%f@#(U%(G0/)0! $GG4%$GA! (K2%$G2%(G/D(%(0$)5 02$b&2A/62#($)$&A2(0I((22#(%(]4%(I()20f@#(I(2#/5 #$0b(() 04GG(00;
64&A$UU&(5 2/2004(502%b42/) 0245(0/62#(2#%((G/IU/4)50f@#(U%(0()20245A5(I/)02%$2(02#$22#(#*#(%2004(0G/)G()2%$2/)
/62#%((G/IU/)()20E(%(/b2$)(5 ) V5)(A!&4)*$)5 #($%2$62(%$0)*&()2%$D()/40$5I)02%$2/) /6/)(0f2BCT1IK0BC.@#(U%(0()2
0245A5(I/)02%$2(02#$22#(2#%((G/IU/4)50#$D(4)(]4$&502%b42/) G#$%$G2(%f:2E$00#/E(5 2#$22#(2#%((G/IU/4)50E(%(I$)&A
502%b42(5 ) $b4)5$)2b&//5;04UU&A2004(004G# $0V5)(A! &4)*$)5 #($%2f:2E$0$&0/6/4)5 2#$2U%/2/G$2(G#4G$G5! 0//%()2) $)5
0G42(&$%) (KG(%(2/) %$U5&A$)5 #$D()/&/)*;2(%I$GG%I4&$2/)f@#(I(2#/5 E$00#/E) 2/b((6(G2D(! G/)D()()2! $)5 042$b&(6/%
0I4&2$)(/400245A2#(502%b42/) /62#(2#%((G/IU/4)50) %$2f
ZAF UBGHK(!./)*G$/)H(G2/)& U%/2/G$2(G#4G$G5& 0//%()2)& 0G42(&$%)& ,8B;<1Z<1& 502%b42/)
HB0.!+ %`#)RT[T..#+!!###(
$
–—$Q
!
¬­
%
/O_PO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP