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期 刊 ：中国中药杂志 2008年 33卷 04期 页码：441.

关键词：雷公藤多苷；复发性肾病(RNS)；细胞因子；

Keywords:triptergium wilfordii polyglycosidium(TWP), rcurrent nephrotic syndrome(RNS), cytokine,

摘 要 ：目的:探讨雷公藤多苷对小儿复发性肾病(RNS)患者Th1/Th2细胞因子的影响。方法:分别设治疗组与健康组。治疗组31例用雷公藤多苷1 mg.kg^-1.d^-1,分3次口服,12周为1疗程。健康组未服任何药物。且在治疗前检测2组血IL-12,IL-2,TNF-,αIL-13,IL-6,IL-4浓度。疗程结束后再测上述细胞因子。结果:治疗组血中除IL-12外其余Th1/Th2细胞因子水平均比治疗前降低(P<0.01)。结论:雷公藤多苷对小儿RNS的Th1/Th2细胞因子(除IL-12外)均有抑制作用,这可能是治疗RNS的重要机制之一。

Abstract:Objective: To study the effect of triptergium wilfordii polyglycosidium on the content of Th1 and Th2 in the treatment child patients of rcurrent nephrotic syndrome.Method: Patients were randomized into treatment group and health group.Sixty-one patients in treatment group were treated with triptergium wilfordii polyglycosidium 1 mg·kg^-1·d^-1 orally tid for 12 weeks.However,patients in health group was not treated with any drugs.Twelve weeks constituted one course of treatment and the content of IL-12,IL-2,TNF-α,IL-13,IL-6,IL-4 in peripheral blood was measured before and behind therapy.Result: In treatment group,the content of serum cytokines behind therapy was significantly lower than that before therapy,except for IL-12.Conclusion: Triptergium wilfordii polyglycosidium could reduce the cytokine level(except for IL-12) of Th1 and Th2,which could lead a therapeutic effect of in the child patients of RNS.

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