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期 刊 ：中国中药杂志 2006年 31卷 05期 页码：383.

关键词：三黄泻心汤；小檗碱；大黄酸；黄芩苷；HPLC；

Keywords:Sanhuang Xiexin decoction, berberine, rhein, baicalin, HPLC,

摘 要 ：目的:研究三黄泻心汤煎液(混悬液)中3种主要药效成分黄芩苷、小檗碱和大黄酸的含量与存在形式。方法:用HPLC测定三黄泻心汤、其拆方配伍及单方煎液中3种成分黄芩苷、小檗碱和大黄酸的含量。结果:在得到的200 mL三黄泻心汤中含黄芩苷1 211 mg,小檗碱276 mg,大黄酸25 mg。尽管黄连中的生物碱与黄芩苷和大黄蒽醌会产生沉淀,但黄芩与黄连之间没有显著影响煎出液中的含量,黄芩能明显促进大黄酸的煎出,黄连与大黄之间则存在很强的抑制煎出的作用。结论:酸性成分与碱性成分之间,酸性成分与酸性成分之间都存在相互影响煎出的情况。

Abstract:Objective: To investigate the content and existing conditions of baicalin,berberine and rhein in Sanhuang Xiexin decoction suspension.Method: Three active components(baicalin,berberine and rhein)in different prescriptions of original,absent one ingredient herb,and single herb were determined by HPLC.Result: There were baicalin 1 211 mg,berberine 276 mg and rhein 25 mg in 200 mL Sanhuang Xiexin decoction.Even though there will be precipitation if alkaloid is together with baicalin and some anthraquinones,no obvious interaction showed the affecting extract content between Scutellaria baicalensis and Coptis chinensis.The extracted rhein content can be increased obviously by Scutellaria baicalensis.Rheum patmatum and Coptis chinensis can suppress medicinal composition releaseof each other.Conclusion: The acid and basic components can affect each other and the acid components themselvesalso can affecteach other.

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