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期 刊 ：中国中药杂志 2006年 31卷 24期 页码：2039.

关键词：大豆苷元；羟丙基-β-环糊精包合物；溶液搅拌法；

Keywords:daidzein, hydropropyl-β-cyclodextrin, solution stirring method,

摘 要 ：目的：制备难溶性药物大豆苷元的羟丙基-β-环糊精包合物,提高其水溶性。方法：采用溶液搅拌法制备包合物,并对包合物进行差示热分析和热重分析、红外光谱、粉末X-射线衍射分析鉴定,最后测定了包合物的稳定常数。结果：在选定条件下制备的包合物中药物含量为6.76%,溶解度为13.68 mg·mL^-1,3种鉴定方法的结果证实形成了包合物。结论：大豆苷元-羟丙基-β-环糊精包合物的制备方法简单可行,达到了增加药物溶解度的目的。

Abstract:Objective: To prepare an inclusion complex of daidzein and hydropropyl-β-cyclodextrin to enhance the solubility of daidzein.Method: The inclusion complex of daidzein was prepared by the solution stirring method. The binary system of daidzein and HP-β-CD was confirmed by differential thermal,thermogravimetry analysis, infrared spectroscopy and X-ray diffractometry.Result: The drug content in the inclusion complex was 6.76% and the solubility was 13.68 mg·mL^-1. The identification results showed that the inclusion complex was formed. Conclusion: The preparation method of the inclusion complex of daidzein and hydropropyl-β-cyclodextrin is simple and available,with a increased solubility of daidzein.

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